EdenteV2, Main, Exploration, bibRecord, 003315

Elucidating role of salivary proteins in denture stomatitis using a proteomic approach†

Identifieur interne : 003315 ( Main/Exploration ); précédent : 003314; suivant : 003316

Elucidating role of salivary proteins in denture stomatitis using a proteomic approach†

Auteurs : Sompop Bencharit [États-Unis] ; Sandra K. Altarawneh ; Sarah Schwartz Baxter [États-Unis] ; Jim Carlson [États-Unis] ; Gary F. Ross [États-Unis] ; Michael B. Border [États-Unis] ; C. Russell Mack ; Warren C. Byrd ; Christopher F. Dibble [États-Unis] ; Silvana Barros [États-Unis] ; Zvi Loewy [États-Unis] ; Steven Offenbacher [États-Unis]

Source :

Molecular bioSystems [ 1742-206X ] ; 2012.

RBID : PMC:3519238

Abstract

Denture stomatitis (DS) is the most common oral pathology among denture wearers, affecting over one-third of this group. DS is usually associated with C. albicans. However, unlike other oral candidiasis, most DS patients have intact host immunity. The presence of a denture alone is usually sufficient for DS. Saliva and its protein contents can theoretically predispose some denture wearers to DS and others resistant toward DS. Here we proposed for the first time to define salivary proteomic profiles of denture wearers with and without DS. SELDI-TOF/MS analysis suggests that there is a proteomic differentiation among control, localized and generalized DS. Based on initial SELDI-TOF/MS profiling, we further used reversed phase liquid chromatography, MALDI-TOF/MS, and LC-MS/MS to characterize the salivary proteins associated with DS. Nineteen proteins based on SELDI-TOF/MS profiling were found including cystatin-SN, statherin, kininogen-1, desmocollin-2, carbonic anhydrase-6, peptidyl-prolyl cis–trans isomerase A like peptides, cystatin C, and several immunoglobulin fragments. The proteomic content gives evidence of the interaction between host tissue, saliva, and candida. Further examination in larger populations of these proteins may help to gain a better understanding of DS pathological processes and improve DS treatments.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519238

DOI: 10.1039/c2mb25283j
PubMed: 23041753
PubMed Central: 3519238

Affiliations:

Le document en format XML

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<author><name sortKey="Bencharit, Sompop" sort="Bencharit, Sompop" uniqKey="Bencharit S" first="Sompop" last="Bencharit">Sompop Bencharit</name>
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<wicri:noCountry code="subfield">USA; Fax: +1 919-966-3821; Tel: +1 919-843-8734</wicri:noCountry>
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<author><name sortKey="Dibble, Christopher F" sort="Dibble, Christopher F" uniqKey="Dibble C" first="Christopher F." last="Dibble">Christopher F. Dibble</name>
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<front><div type="abstract" xml:lang="en"><p id="P1">Denture stomatitis (DS) is the most common oral pathology among denture wearers, affecting over one-third of this group. DS is usually associated with <italic>C. albicans</italic>
. However, unlike other oral candidiasis, most DS patients have intact host immunity. The presence of a denture alone is usually sufficient for DS. Saliva and its protein contents can theoretically predispose some denture wearers to DS and others resistant toward DS. Here we proposed for the first time to define salivary proteomic profiles of denture wearers with and without DS. SELDI-TOF/MS analysis suggests that there is a proteomic differentiation among control, localized and generalized DS. Based on initial SELDI-TOF/MS profiling, we further used reversed phase liquid chromatography, MALDI-TOF/MS, and LC-MS/MS to characterize the salivary proteins associated with DS. Nineteen proteins based on SELDI-TOF/MS profiling were found including cystatin-SN, statherin, kininogen-1, desmocollin-2, carbonic anhydrase-6, peptidyl-prolyl <italic>cis</italic>
–<italic>trans</italic>
 isomerase A like peptides, cystatin C, and several immunoglobulin fragments. The proteomic content gives evidence of the interaction between host tissue, saliva, and candida. Further examination in larger populations of these proteins may help to gain a better understanding of DS pathological processes and improve DS treatments.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
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<tree><noCountry><name sortKey="Altarawneh, Sandra K" sort="Altarawneh, Sandra K" uniqKey="Altarawneh S" first="Sandra K." last="Altarawneh">Sandra K. Altarawneh</name>
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<country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Bencharit, Sompop" sort="Bencharit, Sompop" uniqKey="Bencharit S" first="Sompop" last="Bencharit">Sompop Bencharit</name>
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<name sortKey="Barros, Silvana" sort="Barros, Silvana" uniqKey="Barros S" first="Silvana" last="Barros">Silvana Barros</name>
<name sortKey="Baxter, Sarah Schwartz" sort="Baxter, Sarah Schwartz" uniqKey="Baxter S" first="Sarah Schwartz" last="Baxter">Sarah Schwartz Baxter</name>
<name sortKey="Border, Michael B" sort="Border, Michael B" uniqKey="Border M" first="Michael B." last="Border">Michael B. Border</name>
<name sortKey="Carlson, Jim" sort="Carlson, Jim" uniqKey="Carlson J" first="Jim" last="Carlson">Jim Carlson</name>
<name sortKey="Dibble, Christopher F" sort="Dibble, Christopher F" uniqKey="Dibble C" first="Christopher F." last="Dibble">Christopher F. Dibble</name>
<name sortKey="Loewy, Zvi" sort="Loewy, Zvi" uniqKey="Loewy Z" first="Zvi" last="Loewy">Zvi Loewy</name>
<name sortKey="Offenbacher, Steven" sort="Offenbacher, Steven" uniqKey="Offenbacher S" first="Steven" last="Offenbacher">Steven Offenbacher</name>
<name sortKey="Ross, Gary F" sort="Ross, Gary F" uniqKey="Ross G" first="Gary F." last="Ross">Gary F. Ross</name>
</country>
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Elucidating role of salivary proteins in denture stomatitis using a proteomic approach†

Elucidating role of salivary proteins in denture stomatitis using a proteomic approach†

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